ALLPAIRS is a test design tool tailored for Windows but portable to a wide variety of platforms with a some minor tweaks to the script file. It automates the "all pairs" test design technique, which is a method of intelligently choosing a small number of combinations of values from a potentially astronomically large number of test cases. Common uses of this tool is testing combinations of software features to see if they interact, and trying to generate reasonable combinations of configuration options for configuration testing. Maybe "common" isn't the proper word - few testers seem to be aware of this technique. More people need to be aware of it.
ALLPAIRS is a bit on the frontier. It's a beta quality tool. You'll need to do some background reading beyond the documentation provided with the tool to understand how the technique works and to make sure you're applying it properly, but you don't need to understand the tool implementation to be able to construct the input for the tool and to use the output.
ALLPAIRS does have some notable limitations that are described in this report, though most can be easily worked around by users who are familiar with using scripting languages. ALLPAIRS is also not suitable for users who aren't comfortable with a command-line interface.
Full disclosure: I have known the author, James Bach, on a professional basis for several years.